低氧诱导因子-1α联合p53蛋白在宫颈癌患者中的表达及对预后的影响

摘要

目的 综合分析低氧诱导因子-1α联合p53蛋白在宫颈癌患者中的表达及对预后的影响.方法 应用免疫组化SP法,检测低氧诱导因子-1α、p53蛋白在91例宫颈癌患者(宫颈癌组)、91例宫颈上皮内瘤样变者(宫颈上皮内瘤样变组)、91例宫颈鳞状上皮组织者(对照组)中的表达情况.结果 ①对照组低氧诱导因子-1α阳性率、p53蛋白阳性率分别为0(0/91)、0(0/91),宫颈上皮内瘤样变组低氧诱导因子-1α阳性率、p53蛋白阳性率分别为36.26%(33/91)、36.26%(33/91),宫颈癌组低氧诱导因子-1α阳性率、p53蛋白阳性率分别为68.13%(62/91)、68.13%(62/91),宫颈癌组低氧诱导因子-1α阳性率、p53蛋白阳性率显著高于宫颈上皮内瘤样变组和对照组(P<0.05);②CINⅠ者低氧诱导因子-1α阳性率、p53蛋白阳性率显著低于CINⅡ和CINⅢ者(P<0.05);③宫颈鳞癌、宫颈腺癌p53蛋白阳性率比较无统计学意义(P>0.05).结论 低氧诱导因子-1α联合p53蛋白在宫颈癌患者中的表达发挥着重要作用.%Objective To analyze the expression of hypoxia-inducible factor-1αand p53 protein in cervical cancer and its prognostic significance.Methods Immunohistochemical SP method was used to detect the expression of hypoxia -inducible factor-1αand p53 protein in 91 cervical cancer patients(cervical cancer group),91 cases of cervical intraepithelial neoplasia (cervical intraepithelial neoplasia),91 cases of squamous epithelium of the cervix(control group).Results ①The positive rates of hypoxia-inducible factor-1αand p53 protein in the control group were 0(0/91),0(0/91),the positive rates of hypoxia-inducible factor-1αand p53 protein in cervical intraepithelial neoplasia were 36.26%(33/91),36.26%(33/91),the positive rates of hypoxia inducible factor-1αand p53 protein in the cervical cancer group were 68.13%(62/91),68.13%(P<0.05). The positive rates of hypoxia-inducible factor-1αand p53 protein in cervical group were significantly higher than the cervical intre-aepithelial neoplasia group and the control group(P<0.05).②The positire rates of hypoxia-inducible factor-1αand p53 protein in CINⅠwere significantly lower than CINⅡand CINⅢ(P<0.05).③The positive rate of p53 protein in cervical squamous cell carcinoma and cervical adenocarcinoma was not statistically different.Conclusion The expression of hypoxia-inducible factor-1αand p53 protein plays an important role in cervical cancer.