目的 探讨鸦胆子油乳介入化疗联合养正消积胶囊治疗原发性肝癌的效果及对患者免疫功能的影响.方法 选取98例原发性肝癌患者进行研究,根据随机数字表法,将所有患者分为观察组(n=49)和对照组(n=49).对照组患者采用鸦胆子油乳联合化疗药介入治疗.观察组患者在此基础上加用养正消积胶囊.比较2组患者近期疗效、免疫功能情况、生活质量评分、生存率及不良反应发生率.结果 观察组的有效率和控制率(71.4%,91.8%)显著高于对照组(59.2%,73.5%)(P<0.05).治疗后,观察组CD3+、CD4+、CD8+、CD4+/CD8+及NK均显著高于对照组(P<0.05).观察组QOL评分显著高于对照组(P<0.05).观察组的6个月、12个月生存率(93.9%,71.4%)显著高于对照组(77.6%,49.0%)(P<0.05).观察组的各不良反应发生率显著低于对照组(P<0.05).结论 鸦胆子油乳介入化疗联合养正消积胶囊可有效改善原发性肝癌患者的免疫状态,提高患者生存率及生活质量.%Objective To investigate the effect of bruceolic oil emulsion interventional chemotherapy combined with Yangzhengxiaoji capsule in the treatment of primary liver cancer and the influence on immune function.Methods 98 patients with primary liver cancer,according to the random number table method,were divided into the observation group(n=49)and the control group(n=49).The control group was treated with bruceolic oil emulsion combined with drug intervention.The observation group received Yangzhengxiaoji capsule on the basis of control group.The short-term efficacy,immune function,quality of life score,survival rates and adverse reaction rates were compared between the 2 groups.Results The effective rate and control rate of the observation group(71.4%,91.8%)were significantly higher than those of the control group(59.2%,73.5%)(P<0.05).After treatment,CD3+、CD4+、CD8+、CD4+/CD8+and NK of the observation group were significantly higher than the control group(P<0.05).The score of QOL in the observation group was higher than that of the control group(P<0.05).6-and 12-month survival rates of the observation group(93.9%,71.4%)were significantly higher than those of the control group (77.6%,49.0%)(P<0.05).The incidence of adverse reactions in the observation group was significantly lower than that of the control group(P<0.05).Conclusion Bruceolic oil emulsion interventional therapy combined with Yangzhengxiaoji capsule can effectively improve the immune status of patients with primary liver cancer,and improve the survival rate and the quality of life.
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