亲属活体供肾肾体积与受体体表面积比值对早期移植肾功能的影响

摘要

目的 探讨亲属活体供肾肾体积(RV)与受体体表面积(BSA)比值(RV/BSA)与术后早期移植肾功能的关系.方法 回顾性分析行亲属活体肾移植术的120对供、受体的临床资料.根据RV/BSA将受体分为A组(RV/BSA<65.33 mL/m2),B组(RV/BSA为65.33~76.49 mL/m2),C组(RV/BSA为76.50~96.96 mL/m2), D组(RV/BSA>96.96 mL/m2).比较4组受体术后估算肾小球滤过率(eGFR),分析RV/BSA与受体术后6、12个月eGFR的相关性.结果 A组术后6个月eGFR明显低于B组、C组和D组(t=2.313,2.947,5.903;均为P<0.05).A组术后12个月eGFR亦明显低于B组、C组和D组(t=2.189,2.433,2.909;均为P<0.05).RV/BSA与受体术后6、12个月的eGFR均存在相关性(均为P<0.05).结论 RV/BSA与亲属活体肾移植术后早期移植肾功能密切相关.%Objective To investigate the relationship between the ratio of living related donor renal volume (RV) to recipient body surface area (BSA) (RV/BSA) and early postoperative function of transplanted kidney. Methods Clinical data of 120 pairs of donors and recipients undergoing living related renal transplantation were retrospectively analyzed. According to the RV/BSA ratio, the recipients were divided into group A (RV/BSA<65.33 mL/m2), group B (RV/BSA 65.33~76.49 mL/m2), group C (RV/BSA 76.50~96.96 mL/m2) and group D (RV/BSA > 96.96 mL/m2). The postoperative estimated glomerular filtration rate (eGFR) of recipients was compared among 4 groups. The correlation between the RV/BSA and eGFR of recipients at postoperative 6 and 12 months was analyzed. Results The eGFR at postoperative 6 month in group A was significantly lower than that in groups B, C and D (t=2.313, 2.947, 5.903; all P<0.05). The eGFR at postoperative 12 month in group A was also significantly lower than that in groups B, C and D (t=2.189, 2.433, 2.909;all P<0.05). The RV/BSA was significantly correlated with the eGFR of recipients at postoperative 6 and 12 months (all P<0.05).Conclusions RV/BSA is intimately correlated with the early function of transplanted kidney after living related renal transplantation.