亲属活体供肾动脉轻度狭窄对肾移植受者术后早期肾功能和并发症的影响

摘要

Objective To evaluate the effect of living-related donor renal transplantation with mild renal arterial stenosis upon the early renal function and postoperative complications of the recipients. Methods Clinical data of 1 4 donors and recipients undergoing living-related donor renal transplantation with mild renal arterial stenosis and 50 donors and recipients receiving standard living donor renal transplantation from healthy relatives were retrospectively analyzed. The levels of serum creatinine (Scr ) in the donors were statistically compared between two groups. The serum levels of Scr at postoperative 1 ,3 and 6 months in the recipients were statistically compared between two groups. The survival rate of kidney graft,and the incidences of delayed graft function (DGF),acute rejection and pulmonary infection were compared between two groups. Results Postoperative Scr levels of the donors did not significantly differ between two groups(all P>0. 05 ). The Scr levels of the recipients at postoperative 1 ,3 and 6 months did not significantly differ between two groups (all P>0. 05 ). The survival rate of kidney graft,and the incidences of DGF,acute rejection and pulmonary infection in the recipients did not significantly differ between two groups (all P >0. 05 ). Conclusions Living-related donor renal transplantation with mild renal arterial stenosis exerts no significant effect upon renal function and postoperative complication in the recipients,who are eligible for the donors for renal transplantation.%目的：探讨亲属活体供肾动脉轻度狭窄对肾移植受者术后早期肾功能和并发症的影响。方法回顾性分析14例供肾动脉轻度狭窄的亲属活体肾移植与50例标准亲属活体肾移植供、受者的临床资料。比较两组供者术后血清肌酐（Scr）水平。比较两组受者术后1、3、6个月的Scr水平；比较两组受者移植肾存活率及移植物功能延迟恢复（DGF）、急性排斥反应、肺部感染的发生率。结果两组供者术后Scr水平比较，差异均无统计学意义（均为P＞0.05）。两组术后1、3、6个月Scr水平比较，差异均无统计学意义（均为P＞0.05）。两组受者移植肾存活率，DGF、急性排斥反应、肺部感染的发生率比较，差异亦均无统计学意义（均为 P＞0.05）。结论亲属活体供肾动脉轻度狭窄对肾移植受者术后肾功能和并发症的影响不大，可纳入标准供体供肾范围。