目的：探讨不同发病年龄对子宫内膜癌患者预后的影响。方法选择380例子宫内膜癌患者作为研究对象，其中年龄≤40岁87例，41~59岁190例，≥60岁103例。通过各类随访方式，观察不同发病年龄患者5年总体生存率及无进展生存率，并对预后影响因素进行多因素分析。结果在发病年龄≤40岁、41~59岁、≥60岁患者的5年总体生存率、5年无进展生存率的观察结果中显示，患者年龄越大，5年总体生存率、5年无进展生存率越低，差异有统计学意义（P﹤0.05）；并且患者分期越高，5年总体生存率、5年无进展生存率越低，差异有统计学意义（P﹤0.05）；Cox回归分析结果显示41~59岁和≥60岁的子宫内膜癌患者死亡风险分别是≤40岁患者的3.465倍和5.142倍，41~59岁和≥60岁的子宫内膜癌患者疾病进展的风险分别是≤40岁患者的2.753倍和4.874倍。结论子宫内膜癌患者发病年龄是影响总生存及无进展生存的独立危险因素，患者年龄越大，病理分期越高，所表现出的预后情况越差。%Objective To investigate the influence of age of onset on the prognosis of patients with endometrial carci-noma. Method 380 case of endometrial cancer were retrospectively analyzed, and were stratified as three different age groups as≤40 (87 cases), 41~59 (190 cases), and≥60 (103 cases). The 5-year overall survival (OS) and progression-free survival (PFS) of those patients in various follow-up periods were observed, and the prognostic factors were analyzed. Re-sult In the analysis for all age groups, it was found that, older patients had lower 5-year OS and PFS, with significant differences observed (P<0.05); Besides, more advanced stages were also significantly associated with lower 5-year OS and PFS (P<0.05);In Cox regression analysis, the hazard ratio (HR) of death for patients at 41~59 and≥60 vs≤40 was 3.465 and 5.142, respectively, while the HR of disease progression was 2.753 and 4.874, respectively. Conclusion The age of onset of endometrial cancer is the independent risk factor concerning overall survival and progression-free survival of patients, while more advanced stage is associated with poorer prognosis.
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