系统性红斑狼疮患者补体C3、C4水平变化的临床意义

摘要

目的:观察系统性红斑狼疮(Systemic lupus erythematosus,SLE)患者补体C3、C4水平变化并探讨其临床意义.方法:选取我院2015年1月—2017年4月收治的122例SLE患者以及同期80名健康体检者,分别纳入患者组、对照组进行前瞻性分析.按照SLE患者系统性红斑狼疮疾病活动性指数-2000(SLEDAI-2000)将患者分为轻度活动组(5~9分)、中度活动组(10~14分)、重度活动组(>14分).比较患者组、对照组以及患者不同亚组SLE患者补体C3、C4以及白蛋白(ALB)、高密度脂蛋白胆固醇(HDL-C)等指标变化,运用Pearson相关性分析,计算补体C3、C4与各类实验室指标及SLEDAI-2000评分的相关性.结果:患者组C3、C4、ALB、HDL-C、LDL-C、IgA、IgM低于对照组,其IgG高于对照组,差异有统计学意义(P<0.05).随着患者病情活动度上升,其C3、C4、ALB、HDL-C、LDL-C、IgA、IgM逐渐下降,IgG逐渐上升,差异有统计学意义(P<0.05).C3、C4与ALB、HDL-C、LDL-C、IgA、IgM均呈正相关,与IgG均呈负相关,且C3与SLEDAI-2000呈负相关(P<0.05).结论:SLE患者补体C3、C4水平的下降与病情进展与病情活动度的上升有着密切关联,C3在反映SLE病情活动度方面的价值更为理想 .%Objective: The objective of this study was to observe the alexin C3 and C4 level fluctuation of systemic lupus erythematosus (SLE) patients and to explore its clinical significance. Methods: A total of 122 SLE patients presented in our hospital from January 2015 to April 2017 were selected as the patients group. And 80 healthy individuals were selected as the control group. The patients group was divided into mild activity group (5 to 9 points), moderate activity group (10 to 14 points) and severe activity group (over 14 points) based on the SLE disease activity index-2000 (SLEDAI-2000). The alexin C3 and C4, albumin (ALB) and high density lipoprotein cholesterol (HDL-C) of SLE patients in the patients group, control group and subgroups were compared. The correlation between alexin C3 and C4, the above indexes and SLEDAI-200o score was calculated by Pearson analysis. Results: The level of C3, C4, ALB, HDL-C, LDL-C, IgA and IgM in the patients group were lower than those of the control group, and the level of IgG was higher than that of the control group, the difference was statistically significant (P<0.05). As the range of activity increases, the level of C3, C4, ALB, HDL-C, LDL-C, IgA and IgM was gradually declined, and the level of IgG gradually rose, the difference was statistically significant (P<0.05). The level of C3, C4 was positively correlated with ALB, HDL-C, LDL-C, IgA and IgM, while negatively correlated with IgG, and C3 negatively correlated with SLEDAI-2000 (P<0.05). Conclusion: The decline of alexin C3 and C4 in SLE patients is closely correlated with the disease progression and the rising of disease activity. Alexin C3 has a significant value in predicting SLE disease activity.