Objective To investigate the gamma glutamine carboxylase (GGCX rs699664) genotype distribution in Yunnan Han population and the correlation between GGCX(rs699664)polymorphism and stable dose of warfarin in patient after valve replacement. Some help were given for individu-al use of warfarin in Yunan Han population to improve patients’ medication compliance. Methods Blood samples were collected from 300 patients with taking stable warfarin dose,and the INR of the prothrombin time within the target range at 1.5~3.0. The genotypes were collecting 300 cases of heart valve replacement after taking warfarin, and using the Snapshot technology to detect GGCX (rs699664) genotype and study its genotype and allele frequency. Results 300 objects were studied, 280 cases were detected a result, two alleles were detected A and G, three kinds of genotype: A/A homozygote (24 cases, genotype frequency of 0.0857), heterozygous A/G (137 cases, genotype frequency of 0.4893) homozygous G/G (119 cases, genotype frequency of 0.425). Taking warfarin dose of A/type A was 3.507±1.44mg/d, Type A/G was 3.46±1.236 mg/d, Type of G/G was 3.092 ± l.044 mg/d. Conclusion GGCX (rs699664) gene polymorphism was one of the genetic factors which influenced the stability dose of warfarin in Han population in Yunnan.%目的：探讨γ谷氨酰羧化酶（GGCX）(rs699664)基因在云南汉族人群的分布情况及基因多态性与心脏瓣膜置换术后华法林稳定剂量的相关性，为临床应用华法林初始剂量及维持剂量提供分子遗传学依据。方法采集300例心脏瓣膜置换术后服用华法林，INR值在1.5~3.0病人的外周血，采用 Snapshot 技术检测GGCX(rs699664)基因型，研究其基因型及等位基因频率。结果300例研究对象中，280例检测出结果,共检出A和G 2种等位基因，3种基因型：纯合子A/A（24例，基因型频率为0.0857）、杂合子A/G（137例，基因型频率0.4893）、纯合子G/G（119例，基因型频率为0.425）。服用华法林剂量A/A型为3.507±1.44mg/d；A/G型为3.46士1.236mg/d；G/G型为3.092±l.O44mg/d。结论 GGCX (rs699664)基因多态性是影响云南汉族人群华法林稳定剂量的遗传因素之一。
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