目的：探讨原发性高血压患者出现轻度血脂异常时，依折麦布对其尿微量白蛋白和肱动脉内皮依赖性扩张功能(以下简称FMD)的治疗效果。方法入选原发性高血压患者80例，随机分为依折麦布组(45例)或非依折麦布组(35例)，治疗随防8个月。治疗前及后行血脂水平、肱动脉内皮依赖性扩张功能(FMD)和尿白蛋白/肌酐等检查。结果从表2看出，以上两组病人基线情况相似。依折麦布组接受依折麦布治疗时间约8个月，检查显示指标均显著下降（P<0.01），包括：总胆固醇、LDL胆固醇、尿白蛋白及肌酐；非依折麦布组患者后负荷后1h的FMD明显低于依折麦布组（P<0.05），且依折麦布组后负荷后1h的FMD升高最显著（P<0.01）；依折麦布组和非依折麦布组负荷后4hFMD升高程度比较，组间差异显著（P<0.05），有统计学意义，依折麦布组高于非依折麦布组。结论原发性高血压患者在接受常规降压药物治疗基础上，采用依折麦布改善轻度血脂异常的效果较好，可有效提升肱动脉内皮依赖性扩张功能，并稳定或逆转动脉粥样硬化的进展。%l: Objective To explore the effect of ezetimide on endothelium dependent flow￣mediated vasodilation (FMD) and microalbuminuria in patients essential hypertension.Methods A total of 80 essential hypertensive patients,were randomisedly assigned to conventional anti￣hypertensive drugs plus ezetimide group (ezetimide group,n=45) and conventional anti￣hypertensive drugs group (con-ventional group,n=35). All the patients were treated and followed up for 8 months. The changes of cholesterol, the levels of microalbuminuriaand FMD between baseline and the end of 8 monthes were analysed.Results At the end of 8 months, ezetimide group showed more significantly reduc-tion in total cholesterol, LDL￣C and the levels of microalbuminuria. After 8 month of ezetimide therapy.FMD at 1 hour was significantly higher than that in conventional anti￣hypertensive drugs alone and FMD at 4 hours was also significantly higher than that in conventional anti￣hyperten-sive drugs alone. Conclusions Ezetimide therapy on the basis of conventional anti￣hypertensive drugs treatment yielded better results in the context of improving endothelium dependent flow￣me-diated vasodilation (FMD) and showed favorable effects on arteriosclerosis in hypertensive patients with mild elevation of LDL￣C.
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