重叠综合征的临床治疗

摘要

重叠综合征（OS）是指慢性阻塞性肺疾病（COPD）和阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并发生于同一患者。临床表现主要包括咳嗽、咳痰、气短、夜间睡眠差、白天嗜睡及记忆力减退等，同时易伴低氧血症、肺动脉高压、肺心病等并发症，严重影响了患者的日常生活，增加死亡率。临床中常采用抗感染、化痰止咳、解痉平喘等基本治疗，并及时处理气道梗阻，而气道通畅是改善患者病情和预后的关键。本文对OS的流行病学、病理生理改变、临床特征及治疗进展作一综述，旨在提高OS的治疗水平。%Overlap syndrome (OS) was the combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea hypopnea syndrome (OSAHS) in the same patient.The main clinical manifestations included cough, expectoration, shortness of breath, bad sleep at night, day-time sleepiness and loss of memory etc., also easily associated with hypoxemia, pulmonary hyper-tension, pulmonary heart disease, such as complications, serious impact on the patient's daily life, increase mortality.Clinical often use anti infection, cough and phlegm, relieving asthma and other basic treatment, and timely treatment of airway obstruction and airway unobstructed was the key to improve the disease condition and prognosis in patients with.This article reviewed the epidemi-ology, pathophysiology, clinical features and treatment of OS in order to improve the treatment level of OS.