盐酸曲马多联合阿托品镇痛方法在体外受精-胚胎移植取卵术中的应用

摘要

Objective To observe the analgesic effects of tramadol combined with atropine during the oocyte retrieval operation in assisted reproduction treatment(IVF/ICSI-ET)� Methods Three hundred patients(four hundred cycles of infertility totally)in the Center for Reproductive Medicine were equally assigned into treatment group and control group according to the different analgesia: the former were treated with intramuscular injection of 100 mg tramadol combined with 0�5 mg atropine for analgesia before the operation and the latter with 50 mg pethidine hydrochloride� The two groups were compared in terms of blood pressure,pulse,degree of pains, rate of fertility,rate of cleavage and rate of transplantable embryo� Result There were no differences between them in terms of blood pressure,pulse,pain degree,rate of fertility and rate of cleavage and rate of transplantable embryo(all P > 0�05),but the incidence of adverse effect in the treatment group was significantly lower than that in the control group(P < 0�05)� Conclusion The application of tramadol hydrochloride combined with atropine sulphatev for analgesia during oocyte retrieval operation of IVF-ET is advantageous for its safety,lower incidence of advers effect and stable vital signs�%　　目的探讨盐酸曲马多与阿托品联合镇痛方法应用于辅助生殖治疗取卵术中的应用效果。方法选择本院生殖医学中心实施辅助生殖治疗取卵术的300例（400个周期）患者。按照不同镇痛方法将患者分为治疗组150例（200个周期）和对照组150例（200个周期）。治疗组采用盐酸曲马多100 mg 联合阿托品0�5 mg 于取卵前30 min 肌内注射，对照组采用盐酸哌替啶50 mg 于取卵前30 min 肌内注射。比较两组患者血压、脉搏、疼痛程度和不良反应发生情况及获卵数、受精率、卵裂率、可移植胚胎率。结果两组患者血压和脉搏，疼痛程度及受精率、卵裂率、可移植胚胎率比较，差异无统计学意义（均 P ＞0�05）；治疗组不良反应发生率低于对照组（P ＜0�05）。结论在取卵术中采用盐酸曲马多联合阿托品镇痛，可减少术中不良反应发生率，而且使患者生命体征保持稳定，安全性好，值得临床推广应用。