具有多孔结构的HA/TiO2生物材料的制备工艺研究

摘要

According to the structure and characteristics of natural bone,porous hydroxyapatite HA/TiO2 biomaterial used in bone tissue engineering was prepared using organic foam method combined with high-temperature sintering process. Effects of sintering technique and component of PVB and TiO2 on the structure and performance of this material were all investigated. Results showed that at an appropriate sintering temperature of 1200℃. ,the product obtained after 3 hours sintering was primarily with the phase of HA and TiO2. The porous HA/TiO2 ceramic material,with larger pore size in the range from 300 μm to 1000 μm and small one in the range from 50 μm to 300μm,has preferable aperture structure with good connectivity and distribution,being favorable for cell and tissue growth and alimentation transportation. TiO2 has an enhancing effect on the compressive strengthen of HA/TiO2 composites which increases with an increase in the content of TiO2,reaching an optimal strength at an optimum content of 5% TiO2,with the material mechanical properties closer to that of cancellous bones. However,more addition of TiO2 will otherwise result in an increase in the fragility of material.%以聚氨酯为造孔支架模板,采用有机泡沫法与高温烧结法,制备了多孔HA/TiO2陶瓷支架材料.讨论了烧结保温时间、PVB含量、TiO2含量等对材料结构与性能的影响.研究表明:较佳的烧结工艺为1200℃烧结3h,烧结后样品主要是HA、TiO2相.多孔HA/TiO2陶瓷拥有大孔径300～1000μm,也有50～300μm的小孔径,具有较好的孔连通性与孔结构,有利于细胞和组织的生长以及营养输送.TiO2具有增强效应,其含量增加,材料压缩强度提高,但TiO2含量过高会增加其脆性,最佳含量为5％,此时材料力学性能接近于人体松质骨.