CHP1002抗炎镇痛作用评价

摘要

Objective To evaluate the anti-inflammatory and analgesia effect of a PEG modified compound CHP1002 on animal models. Methods Using the ear swelling test in mice, the paw edema test in rats, and the acetic acid-induced pain test in mice, the anti-inflammatory effect of CHP1002 ( 220,440 and 880 mg/kg ) was evaluated and its anti-inflammatory and analgesia effect was compared with the prototype drug at different time after administration. Results In all the three animal models, the anti-inflammatory effect of CHP1002( 440 and 880 mg/kg ) ( P <0. 01 )was observed, and subcutaneous injection had analgesia effect ( P <0. 01 ). In comparison with the prototype drug, the anti-inflammatory and analgesia effect of CHP1002 was prolonged at different time after administration( P < 0. 05 ). Conclusion The PEG modified compound CHP1002 has anti-inflammatory and analgesia effect and prolongs the action time.%目的 研究穿琥宁经PEG修饰的新化合物CHPl002的抗炎镇痛作用.方法 分别采用小鼠耳肿胀实验、大鼠足肿胀实验、小鼠醋酸扭体实验观察不同剂量(220,440.880 mg/kg)CHPl002的抗炎镇痛作用,以及给药后不同时间与原型药物的抗炎药效的比较.结果 动物腹腔注射CHPl002 440、880 ms/ks剂量组具有抗炎作用(P