Mechanism of shaoyao gancao decoction on anti-inflammatory and analgesic effects by molecular docking

摘要

According to the components absorbed into blood of Shaoyao Gancao decoction, we chose COX-2 which is responsible for the elevated production of prostaglandins during inflammation as the target for molecular docking. The mode of action between small molecules and the targets were presented visually, which provided an in-depth interpretation about the pharmacodynamic material basis. The results reveal treatment mechanism and pharmacodynamic material basis of Shaoyao Gancao decoction for antiinflammatory and analgesic effects. Using pattern recognition technology to analyze the interaction between these components and the target provides a theoretical basis for the further development of related drugs.