The US Project BioShield is a ten-year plan to respond to chemical, biological, radiological and nuclear (CBRN) threat agents. So far, the US government has appropriated $ 5. 567billion for the program. The development and acquisitions under Project BioShield are vaccines and therapeutic drugs which are used to address each of the above 4 threat agents, including Bacillus anthracis( anthrax) .smallpox virus, botulinum toxins, chemical and radiological agents. The implementation of Project BioShield has improved the ability to respond to CBRN terrorist attacks, promoted the development and transfer of basic research products and preclinical development, and enhanced the management system of biodefense scientific research.%生物盾牌计划是美国应对核化生放(CBRN)等大规模杀伤性武器威胁的一项十年计划.截至目前,生物盾牌计划共获拨款55.67亿美元,研发并储备了炭疽芽孢杆菌、天花病毒、肉毒毒素疫苗以及化学、放射和核损伤的治疗药物.生物盾牌计划的实施提升了美国应对CBRN恐怖袭击能力,促进了生物医药基础研究和临床前期产品的研发与转化,推动了美国生物防御体系的完善.
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