埃博拉病毒复制、转录和翻译过程中宿主互作因子的研究进展

摘要

Ebola virus(EBOV) disease,the fatality rate of which is as high as 25％-90％,can be transmitted by contac t between human and non-human primates.Early studies of the virus focused on the functions of viral proteins.Recently,the focus of research of EBOV has been switched to the host interaction factors during the process of virus reproduction.In this review,advances in studies on host contributions to EBOV replication,transcription and translation are summarized in order to enhance our understanding of contributions of the host to the virus reproduction process and provide reference for research strategies and new antiviral drugs.%埃博拉病毒(EBOV)是一种可在人类及非人灵长类间通过接触传播的烈性病原微生物,致死率25％～90％.针对该病毒的早期研究主要聚焦到病毒自身蛋白的作用,但近年来,研究重心逐渐转向病毒增殖过程中宿主相互作用因子的研究.该文综述了EBOV在复制、转录和翻译过程中宿主互作因子的研究进展,旨在增强对EBOV在胞内增殖过程中与宿主细胞相互作用情况的了解,为今后制定研究策略、开发新型抗病毒药物提供理论参考.