免疫细胞异常在SLE发病机制中的作用

摘要

Systemic lupus erythematosus( SLE )is a multi-organ autoimmune disease which is caused by the production of varied autoantibodies and immune complex. The induction, maintenance and progression of the disease are a multi-step process that may take a long time, eventually leading to tissue injuries. Its pathogenesis is complicated involving genetic, environmental factors, and abnormalities of immune system, among which, abnormal immune system plays an important role. Dendritic cell,T cell and B cell are important immune cells in immune system. Here is to make a review on the current researches of the abnormalities of the three kinds of immune cells in SLE pathogenesis.%系统性红斑狼疮(SLE)是一种由多种自身抗体及免疫复合物引起多器官损伤的自身免疫性疾病,疾病的诱发、持续和进展是多步骤的过程,迁延漫长,最终导致组织损伤.其发病机制复杂,涉及基因、环境、免疫系统异常等,其中免疫系统异常居重要地位.树突状细胞、T细胞、B细胞是免疫系统重要的免疫细胞.现就近年来SLE发病机制中这三种免疫细胞异常的研究进展进行综述.