伊班膦酸钠在乳腺癌骨转移中的作用

摘要

Bone metastasis from breast cancer often cause significant symptoms, such as pain, impaired function,pathological fracture,and spinal cord compression etc.. Bisphosphonates play an important role in preventing these skeletal related events and are the standard therapeutic drugs for patients with bone metastasis from breast cancer. Ibandronate is a highly potent bisphosphonate available in both intravenous and oral preparations,and it is also effective in high doses for palliation of opioid-resistant pain from bone metastasis. Unlike other intravenous bisphosphonates, ibandronate has minimal renal toxicity, allowing safe outpatient administration and safety monitoring,reducing the need for hospitalization.%乳腺癌所引起的骨转移常引起疼痛、功能障碍、病理性骨折、脊髓压迫等明显的症状.双膦酸盐在防治骨骼并发症中起重要作用,已成为乳腺癌骨转移的标准性治疗药物.伊班膦酸钠是第三代高效能的双磷酸盐制剂,可静脉注射或口服给药,对中重度阿片类药物抵抗的转移性骨痛具有显著缓解作用.与其他静脉给药的双膦酸盐相比,伊班膦酸钠有较小的肾毒性及较好的安全监测性,方便门诊患者应用,从而减少住院需求.