目的 评价血清胆碱酯酶(CHE)、腺苷脱氨酶(ADA)和总胆汁酸(TBA)的联合检测对不同病期肝病患者的临床价值.方法 选择2011年3月至2012年2月在成都市传染病医院确诊的肝病患者151例和同期健康体检者120例(对照组),采用日立7180全自动生化分析仪检测样本血清CHE、TBA和ADA的水平,同时测定与其密切相关的血清学指标,包括丙氨酸氨基转移酶(ALT)、前白蛋白(PA)和总胆红素(TBIL).结果 ALT、TBIL、TBA和ADA在肝病患者均显著增高,与对照组比较差异有统计学意义(P＜0.05),CHE和PA在肝病患者均显著偏低,与对照组比较差异有统计学意义(P＜0.01);CHE、TBA和ADA的阳性率均在83.0%以上,与相关的血清学指标比较,差异有统计学意义(P＜0.05).结论 CHE、TBA和ADA的联合检测有助于肝病的诊断和疗效观察以及预后的判断,为临床医师提供可靠、准确、有价值的临床诊断指导依据,具有较好的临床应用价值.%Objective To evaluate the clinical value of serum of cholinesterase(CHE),adenosine de-aminase( ADA ) and the total bile acid ( TBA ) jointing inspection for liver diseases of different stages.Methods 151 confirmed cases from Infectious Diseases Hospital of Chengdu in March 2011 to February 2012 and 120 oases of healthy check-up( control group ) were selected,the Hitachi 7180 automatic biochemistry analyzer was used totest sample serum CHE,TBA and ADA content, and the closely related serological index ( ALT, PA, TBIL ) content was tested as well, including alanine aminotransferase ( ALT ), prealbumin ( PA ) and total bilirubin ( TBIL ).Results ALT,TBIL,TBA and ADA in patients with liver disease were significantly increased,the difference from the control group was statistically significant( P<0.05 ), CHE and PA in liver disease patients were significantly lower, the difference was statistically significant( P < 0.01 ); CHE, TBA and ADA positive rate were above 83.0% and the difference was statistically significant compared with the related serological indexes ( P <0.05 ).Conclusion CHE, TBA and ADA's united detection is helpful for liver disease diagnosis and curative effect and prognosis judgment,which can provide reliable,accurate and valuable clinical diagnosis guidance for doctors,and has a good clinical application value.
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