血清降钙素原及白细胞介素6水平在新生儿败血症早期诊断中的临床价值

摘要

Objective To study the clinical l value of serum procalcitonin and interleukin-6 level in ear-ly diagnosis of neonatal sepsis. Methods 100 cases of neonatal sepsis patients were enrolled in septicemia group and 100 cases of newborn infants during the same period were enrolled healthy group. Then serum pro-calcitonin and interleukin-6 level were detected, general condition were judged by SOFA score and PCIS score. Results PCT、IL-6 level and SOFA score(8.8 ±1.3)of septicemia group were higher than healthy group [(13.8 ±2.5) μg/L vs (2.8 ±0.1) μg/L,(272.9 ±43.6) ng/L vs (58.5 ±8.2) ng/L,(8.8 ± 1.3) scorevs(2.3±0.5) score]( (P<0.05).PCISscorewaslowerthanhealthygroup[(72.1±11.4) scorevs(095.8±13.1)score]((P<0.05).SOFAscorewerepositivelycorrelatedwithPCT,IL-6level, PCIS score was negatively correlated with PCT,IL-6 level(P<0. 05);Sensitivity and specificity of PCT,IL-6 joint detection were separately 94% and 96%,which were higher than single detection(P<0. 05). Con-clusion PCT,IL-6 levels are increased in neonatal sepsis and closely related to the severity of disease,com-bined detection of two indexes can improve the sensitivity and specificity.%目的：研究血清降钙素原( PCT)及白细胞介素6( IL-6)水平在新生儿败血症早期诊断中的临床价值。方法将2011年1月至2012年12月期间在高州市人民卫生院就诊的100例新生儿败血症患者纳入败血症组,同期分娩的100例健康新生儿纳入健康组,采集外周血检测PCT及IL-6水平,并通过序贯器官功能衰竭评估( SOFA)评分、危重评分系统( PCIS)评分判断全身情况。结果与健康组比较,败血症组患儿PCT、IL-6水平及SOFA评分均高于健康组[(13.8±2.5)μg/L vs (2.8±0.1)μg/L,(272.9±43.6) ng/L vs (58.5±8.2) ng/L,(8.8±1.3)分vs (2.3±0.5)分],PCIS评分低于健康组[(72.1±11.4)分 vs(95.8±13.1)分],差异均有统计学意义(P<0.05)；SOFA评分与PCT、IL-6水平呈正相关(P<0.05),PCIS评分与PCT、IL-6水平呈负相关(P<0.05)；PCT、IL-6两项指标联合检查灵敏度为94%、特异度为96%,均高于两项指标单独检测(P<0.05)。结论新生儿败血症患者的PCT及IL-6水平明显升高,且与疾病的严重程度密切相关,两项指标联合检测可提高敏感性和特异性。