Objective To research the characteristics of C-reactive protein(CRP),fibrinogen(Fib), and N-terminal pro-brain natriuretic peptide(NT-proBNP) in patients with chronic or persistent atrial fibril-lation possibly complicated with heart failure or early symptoms of heart failure .Methods From Jan.2009 to Jun.2013,a retrospective analysis on 78 patients with atrial fibrillation or atrial fibrillation complicated with other complications in Department of Cardiology of Shiyan Traditional Chinese Medicine Hospital was done , including 21 patients with atrial fibrillation complicated with severe heart failureas group A;34 patients with persistent atrial fibrillation with heart failure with obvious early symptoms as group B;23 patients with parox-ysmal atrial fibrillation as group C.30 normal healthy people were selected as controls(group D).The serum levels of CRP,Fib,NT-proBNP of group A,B,C,D were detected.Results The level of CRP in group A, B,C and D was (120.3 ±22.7),(50.3 ±15.7),(15.7 ±1.3) and (3.7 ±1.2) mg/L and the difference was statistically significant (P<0.01).Fib in four groups were (287.2 ±38.3),(41.2 ±11.6),(287.2 ± 0.8) and (2.7 ±0.3) mg/L,and the difference was statistically significant(P<0.05).The Fib in group A was the highest among the four groups.NT-proBNP were (1092.8 ±218.3),(692.4 ±101.5),(395.3 ± 51.8) and (172.4 ±32.0) ng/L,and the difference was statistically significant(P<0.01).There was pos-itive correlation between CRP/Fib and NT-proBNP in group B ( P <0.05 ) , but in group C only CRP and T-pro BNP had positive correlation (P<0.05).Conclusion CRP,Fib and NT-pro BNP levels in serum in patients with atrial fibrillation complicated by heart failure are significantly higher than that of normal healthy population,and joint diagnosis can improve the diagnostic sensitivity of concurrent heart failure and make early clinical intervention.%目的：探究慢性或持续性心房颤动（房颤）并发心力衰竭（心衰）或伴有心衰前期症状患者血清C反应蛋白（CRP）、纤维蛋白原（Fib）、氨基末端脑钠肽前体（NT－proBNP）特点。方法回顾性分析2009年1月至2013年6月十堰市中医医院住院治疗的78例房颤或者房颤并发其他并发症患者，其中房颤并发重度心衰21例（ A 组）；持续性或持久性房颤伴明显心衰前期症状患者34例（ B组）；阵发性房颤患者23例（ C组）。同时选取对照组健康正常人群30例（ D组）。 A、B、C组患者入院时抽血，D组抽血时间不定，检测血清CRP、Fib、NT－proBNP水平。结果 A、B、C和D四组CRP水平分别为（120．3±22．7）、（50．3±15．7）、（4．1±1．3）mg／L和（3．7±1．2）mg／L，4组间差异有统计学意义（P＜0．01）；4组Fib分别（287．2±38．3）、（41．2±11．6）、（4．5±0．8） mg／L和（2．7±0．3） mg／L，其中A组Fib水平显著高于 B、C、D 组，差异有统计学意义（ P ＜0．05）；NT－proBNP分别为（1092．8±218．3）、（692．4±101．5）、（395．3±51．8） ng／L 和（172．4±32．0） ng／L，差异有统计学意义（P ＜0．01）。 CRP、Fib和NT－proBNP在房颤伴有心衰患者血清中升高呈正相关（P＜0．05），但是在C组仅CRP与T－proBNP呈正相关（P＜0．05）。结论 CRP、Fib和 NT－proBNP在房颤并发早期心衰患者血清中水平升高，明显高于正常健康人群血清水平，联合诊断可以提高房颤并发早期心衰诊断敏感性，使得临床及早干预。
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