联合检测慢性心力衰竭患者血清NT-proBNP、hs-CRP和cTnI的临床意义

摘要

Objective To explore the clinical significance of joint detection of serum N-terminal pro-B-type natriuretic peptide (BNP), high sensitive C-reactive protein(hs-CRP) and cardiac troponin I(cTnI) in the diagnosis of chronic heart failure(CHF). Methods According to the criteria of American New York Heart Association(NYHA), their heart functions of the 100 patients with CHF were classified into level I-IV, and select the healthy control group 30 subjects. The levels of serm NT-proBNP, hs-CRP and cTnI were detected and analyzed in the CHF group and the control group. Results Compared with the control group, the levels of NT-proBNP、hs-CRP in CHF NYHA I grade group were significantly higher(P<0.05), the level of cTnI was no significantly difference(P>0.05);The levels of NT-proBNP, hs-CRP and cTnI had statistical significance in different grades of CHF(P<0.05);The NYHA class was worse, and the levels of three indicators were significantly higher. Conclusion NT-proBNP is a good cardiac marker for the diagnosis of CHF, joint detection of serum NT-proBNP, hs-CRP and cTnI levels provide reference supporty in the early diagnosis of CHF.%目的：探讨血清氨基末端B型钠尿肽前体(NT-proBNP)、超敏C反应蛋白(hs-CRP)和心肌肌钙蛋白I(cTnI)的联合检测在慢性心力衰竭(CHF)诊断中的临床意义。方法将100例CHF患者按美国纽约心脏病协会(NYHA)分级方案分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级，同时检测100例CHF患者和30例正常对照组NT-proBNP、hs-CRP和cTnI水平。结果CHF患者不同心功能分级组间血清NT-proBNP、hs-CRP和cTnI水平差异有统计学意义(P<0.05)，并且随着心力衰竭严重程度的加重而增高；NYHAⅠ级患者的血清NT-proBNP、hs-CRP检测水平与对照组比较差异有统计学意义(P<0.05)， cTnI检测水平差异无统计学意义(P>0.05)。结论NT-proBNP是诊断CHF较好的心肌标志物，联合检测血清NT-proBNP、hs-CRP和cTnI水平可为慢性心力衰竭(CHF)提供诊断依据，且其升高幅度与病情的严重性相一致。