ADAMTS-13的功能调节及其与心血管疾病的研究进展

摘要

Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶（ADAMTS）13于2001年首次发现并克隆，属于含Ⅰ型血小板反应蛋白的解聚素和金属蛋白酶家族成员，为人血管性血友病因子裂解蛋白酶。 ADAMTS－13主要由血管内皮细胞、肝星状细胞及骨骼肌细胞等细胞合成和分泌，其水平异常是多种疾病的风险因素，如血栓性血小板减少性紫癜、先兆子痫及恶性疟疾。近年来发现，ADAMTS－13功能异常与心血管疾病的发生、发展密切相关，该文就 ADAMTS－13与心血管疾病的研究进展予以综述。%ADAMTS13 ( a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13),firstly identified and cloned in 2001,is a member of the ADAMTS family.It also acts as a plasma reprol-ysin-like metalloprotease,which cleaves von Willebrand factor.ADAMTS-13 is mainly synthesized and secre-ted by endothelial cells,hepatic stellate cells and skeletal muscle cells.Abnormal level of ADAMTS-13 is a risk factor for a variety of diseases,such as thrombotic thrombocytopenic purpura,preeclampsia and malignant malaria.In recent years,it′s found that ADAMTS-13 dysfunction is closely related to the development of car-diovascular disease,therefore here makes a review of the progress of ADAMTS13 in cardiovascular disease.