PGC-1beta-protein-function regulator, mitochondria-function regulator, anti-obesity agent, and screening method therefor

摘要

[Problem];To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore.;[Solution];The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1β-protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1β protein; and (3) the ubiquitination of the PGC-1β protein by synoviolin.