Objective To study the effect of puerarin combined with compound anisodine injection on patients with ocular fundus and the influence on hemorrheology indicators .Methods Total of 100 patients with ocular fundus in Mianyang Third People′s Hospital from Apr.2013 to Apr.2014 were selected,and were divided into observation group and control group according to random drawing lots method,50 cases each.The control group used puerarin treatment(0.4 g puerarin added to 250 mL saline for intravenous infusion,1 time per day,14 d as a course,treatment course interval 3 d) ,the observation group was added compound anisod-ine injection on the basis of the control group′s treatment plan( 2 mL compound anisodine subcutaneously in-jected from superficial temporal artery,1 time per day,14 d as a course,treatment course interval 3 d,then changed the injection site to Shenshu point during the second course,then treatment course interval 3 d,then back to the first course treatment regimen).After three courses,the hemorrheology changes,the recurrence rate and adverse reactions,and outcomes of the two groups were compared.Results After treatment,whole blood viscosity in the observation group (4.82 ±0.41) mPa・ s was significantly lower than the control group (5.56 ±0.39) mPa・ s,erythrocyte aggregation index 3.80 ±0.41 was significantly lower than the control group 4.77 ±0.55,fibrinogen (4.20 ±0.24) g/L was significantly lower than the control group (5.25 ± 0.43) g/L,the differences of hemorrheology between the two groups of patients after treatment were statisti-cally significant (t=9.247,9.998,15.077,P <0.01); the recurrence rate of the observation group was 2.0%(1/50),the overall incidence of adverse reactions was 4.0%(2/50) lower than the control group′s 14.0%(7/50) and 18.0%(9/50) respectively(P<0.05);total effective rate of the observation group was 98.0%(49/50),significantly higher than the control group′s 82.0%(41/50)(P <0.01).Conclusion Puerarin joint compound anisodine injection can effectively improve hemorrheology of patients with ocularfundus disease and the improve clinical outcomes .%目的：研究葛根素联合复方樟柳碱注射液对眼底病患者的治疗效果及对血液流变学指标的影响。方法选择2013年4月至2014年4月在绵阳市第三人民医院眼科进行眼底病治疗的患者100例，并按入院顺序抽签随机分为观察组和对照组，各50例。对照组进行葛根素常规治疗（葛根素注射液0．4 g加入生理盐水250 mL中静脉滴注，每日1次，1个疗程14 d，1个疗程后停药3 d，再进行下一疗程），观察组在此基础上联合复方樟柳碱注射液进行治疗（采用复方樟柳碱2 mL在患者颞浅动脉旁行皮下注射，每日1次，1个疗程14 d，完成1个疗程后停药3 d，再换肾俞穴进行注射，1个疗程后停药3 d，再进行第一个疗程的用药）。3个疗程后，比较两组患者治疗前后血液流变学的变化、术后复发率和不良反应情况及患者的治疗效果。结果治疗后，观察组全血黏度为（4．82±0．41） mPa・ s明显低于对照组的（5．56±0．39） mPa・ s，红细胞聚集指数（3．80±0．41）明显低于对照组（4．77±0．55），纤维蛋白原（4．20±0．24） g／L明显低于对照组（5．25±0．43） g／L，差异均有统计学意义（t＝9．247，9．998，15．077，P＜0．01）；观察组患者治疗后复发率为2．0％（1／50），不良反应的总发生率为4．0％（2／50），分别低于对照组14．0％（7／50）和18．0％（9／50）（P＜0．01）；观察组患者的总有效率为98．0％（49／50），显著高于对照组的82．0％（41／50）（P＜0．05）。结论葛根素和复方樟柳碱注射液联合治疗眼底病患者，可改善患者血液流变学，并提高临床治疗效果。
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