原发性肺弥漫大B细胞淋巴瘤的临床病理分析

摘要

肺原发性淋巴瘤是非霍奇金淋巴瘤中一种罕见类型.大多数肺原发性淋巴瘤属于低级别、黏膜相关淋巴瘤类型,而原发性肺弥漫大B细胞淋巴瘤(DLBCL)极其罕见,仅见于10%的肺原发性非霍奇金淋巴瘤.原发性肺DLBCL由于缺乏特异性的症状和体征,极易误诊.尽管目前该病的临床特征、诊断标准、最佳治疗方案和预后因素还没有很好的定义,但在先前的研究中,开胸肺活检或胸部CT引导下的经皮活检是获取标本的最好方法.而最终诊断要以组织病理学形态为基础并与免疫组织化学相结合.及时诊断和在疾病早期阶段就开始化疗对患者的预后至关重要.%Primary pulmonary lymphoma(PPL) is an uncommon type of non-Hodgkin′s lymphoma.The majority of PPL are low-grade,mucosa-associated lymphoid tissue type.Primary pulmonary diffuse large B-cell lymphoma(DLBCL) is par-ticularly rare and occurs only in 10%cases of primary pulmonary non-Hodgkin′s lymphoma .The rapid diagnosis of primary pulmonary DLBCL is challenging since the clinical symptoms and signs are nonspecific .Although the clinical features ,diag-nostic procedure ,optimal management and prognostic factors of this disease are yet to be clearly elucidated ,previous studies indicated that open thoracotomy and chest computed tomography-guided percutaneous biopsy are the preferred methods of diagnosis .The final diagnosis depends ultimately on histopathological and immunohistochemical analysis ,and prompt patho-logical diagnosis and initiation of chemotherapy are crucial to the prognosis .