Objective To investigate correlations between serum matrix metalloproteinase-2 (MMP-2), matrix metalloproteinases-9 (MMP-9) with tissue inhibitor of metalloproteinase-1 (TIMP-1) and carotid atherosclerosis and cal-cium phosphate metabolism in patients undergoing maintenance hemodialysis(MHD). Methods A total of 86 MHD pa-tients admitted during January 2010 and December 2016 were divided into group A (n=40) and group B (n=40) ac-cording to whether or not having carotid atherosclerosis, and other 40 healthy people tahing medical examination at the same period were selected as control group. Levels of MMP-2,MMP-9,TIMP-1,typeⅠcollagen N terminal and calci-um phosphate metabolism were observed,and correlations among the above indicators in MHD patients were analyzed in three groups. Results In group A and B, MMP-2, MMP-9 and intima mean thickness (IMT) levels were significantly higher than those in control group,and the levels in group A were significantly higher than those in group B(P<0.05);TIMP-1 levels were significantly lower than that in control group,and the level in group A was significantly lower than that in group B(P<0.05);levels of phosphorus3-(P3-),alkaline phosphatase(ALP),typeⅠcollagen N terminal and Ca× P were significantly higher than those in control group, and the levels in group A were significantly higher than those in group B(P<0.05);Ca2+levels were significantly lower than that in control group,and the level in group A was signifi-cantly lower than that in group B(P<0.05). MMP-2 and MMP-9 were positively correlated with IMT,Ca × P and typeⅠcollagen N terminal,and TIMP-1 was negatively correlated with IMT,P3-,Ca × P and typeⅠcollagen N terminal(P<0.05). Conclusion Close correlations have been detected between MMP-2,MMP-9 and TIMP-1 with IMT,P3-,Ca × P and typeⅠcollagen N terminal in patiens undergoing MHD,and therefore clinicians may judge the occurrence possibility of bad MHD cardiovascular events and degree of calcium phosphate metabolism disorders by monitoring the above levels.%目的 探讨维持性血液透析(MHD)患者血清基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)、金属蛋白酶组织抑制剂-1(TIMP-1)与颈动脉硬化及钙磷代谢相关性.方法 选取2010年1月—2016年12月济宁医学院附属湖西医院肾内科86例MHD患者,根据MHD患者有无颈动脉硬化分为A组和B组,选择同期体检正常者40例为对照组.观察3组MMP-2、MMP-9、TIMP-1、Ⅰ型胶原氨基末端肽(sNTX)及钙磷代谢水平,分析MHD患者上述指标相关性.结果 A、B组MMP-2、MMP-9水平和IMT均明显高于对照组,且A组高于B组(P<0.05);A、B组TIMP-1低于对照组,且A组低于B组(P<0.05);A、B组P3-、ALP和sNTX以及钙磷代谢水平高于对照组,且A组高于B组(P<0.05);A、B组Ca2+低于对照组,且A组低于B组(P<0.05).MMP-2和MMP-9与IMT、钙磷代谢和sNTX之间呈正相关,TIMP-1与IMT、P3-、钙磷代谢和sNTX之间呈负相关(P<0.05).结论 MHD患者血清MMP-2、MMP-9、TIMP-1和IMT、P3-、钙磷代谢和sNTX之间均存在着密切联系,可通过监测上述指标水平判断MHD心血管不良事件发生可能性和钙磷代谢紊乱程度.
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