血清同型半胱氨酸和脂蛋白（a）与中青年缺血性脑卒中患者的相关研究

摘要

目的：：研究血清同型半胱氨酸( Hcy)和脂蛋白[ Lp ( a)]水平与中青年缺血性脑卒中患者之间的关系,指导临床上缺血性脑卒中患者的预防和治疗。方法：选取168例中青年缺血性脑卒中患者设为脑卒中组；100例健康体检者设为对照组。检测两组研究对象的血清Hcy和Lp (a)水平,并进行统计学分析；同时检测脑卒中患者C-反应蛋白(CRP)、纤维蛋白原和血脂水平,分析与Hcy和Lp(a)相关性。结果：脑卒中组患者血清Hcy (17.63±10.09)μmol/L和Lp (a)(287.37±177.34) mg/L水平及异常检出率均显著高于对照组(Hcy10.05±3.89μmol/L,Lp(a)150±101.81) mg/L(P<0.001)；脑卒中组患者Hcy与Lp(a)之间无相关性,同时Hcy和Lp(a)分别与CRP、纤维蛋白原和血脂水平均无相关性。结论：血清Hcy和Lp( a)水平升高都是引发中青年缺血性脑卒中患者的重要的独立危险因素,对预测脑血管疾病的发生有重要价值。%Objective: To study correlations among serum homocysteine, lipoprotein ( a) and ischemic stroke in young and mid-aged adults in order to contribute to prevent and treat ischemic stroke. Methods:168 young and mid-aged patients with ischemic stroke were selected as stroke group, while 100 healthy persons at the same time were selected as control group. Their homocysteine and lipoprotein ( a) levels were tested and statistically analyzed. At the same time, the C-reactive protein, fibrinogen and blood fat levels of the stroke patients were determined, and their correlations with homocysteine and lipoprotein ( a) were analyzed. Results:The serum homocysteine (17. 63±10. 09 μmol/) and lipoprotein (a) (287. 37±177. 34 mg/L) levels and their abnormal detection rate of stroke group were significantly higher than those of control group (P<0. 001). There were no correlation between homocysteine and lipoprotein ( a) , and there were also no correlations among serum homocysteine, lipoprotein ( a) and the C-reactive protein, fi-brinogen and blood fat levels. Conclusions:The serum's homocysteine and lipoprotein ( a) levels are the independent risk factors to cause ischemic stroke in the youth and mid-aged adults, and have an important value for the prediction of cerebrovascular diseases.