加巴喷丁在全膝关节置换术后镇痛效果中的前瞻性研究

摘要

Objective:To investigate the analgesic effect of Gabapentin in the evaluation of pain management after total knee arthroplasty (TKA).Method:Randomized, double-blind, placebo controlled from October 2016 and February 2018, 80 patients underwent unilateral TKA were randomly divided into two groups, 40 cases each in each group.After surgery, Gabapentin group took Gabapentin Capsules regularly and placebo group took Lactose Placebo Capsules, the analgesic effects of two groups were compared.Result:Gabapentin Capsule, as an assistant analgesic drug in multi-mode and multi-link pain management, can effectively improve the pain in 48 h after surgery.At the same time, it significantly improved the functional recovery in the early (7 d) after knee surgery, and there was no obvious drug adverse reaction.However, there was no statistical significant difference in the recovery of knee joint function between two groups at the six-month follow-up (P＞0.05).Conclusion:Gabapentin Capsule has a definite analgesic effect. It can effectively relieve pain after total knee arthroplasty, promote early joint activity, shorten hospitalization time, and do not increase adverse drug reactions.It is an ideal analgesic drug.%目的:研究加巴喷丁在全膝关节置换术后疼痛管理中的镇痛效果.方法:采用随机双盲安慰剂对照的方法, 将2016年10月-2018年2月西南医科大学附属中医医院骨伤科拟行初次膝关节置换的患者80例纳入研究, 按照随机量表法将患者分为两组 (加巴喷丁组40例和安慰剂组40例), 每个加巴喷丁组的患者术后定期加服加巴喷丁胶囊, 安慰剂组术后服用乳糖胶囊安慰剂, 比较两组的镇痛效果.结果:加巴喷丁胶囊作为多模式多环节疼痛管理中的辅助镇痛药物能有效地改善术后48 h内的疼痛, 同时明显改善患膝术后早期 (7 d) 的功能恢复, 且未出现明显药物不良反应.但在6个月的随访中发现两组患者的膝关节功能恢复差异无统计学意义 (P＞0.05) .结论:加巴喷丁胶囊辅助镇痛作用确切, 可有效地缓解全膝关节置换术患者术后的疼痛, 促进全膝关节置换术患者早期进行关节活动, 缩短住院时间, 且不会增加药物不良反应, 是较为理想的镇痛药物.