干扰素治疗慢性丙肝所致间质性肺炎的临床特征分析

摘要

目的：探讨分析干扰素治疗慢性丙肝所致间质性肺炎的临床特征。方法：选取本院2008年1月-2012年12月期间运用干扰素治疗慢性肝病所致间质性肺炎患者8例，其中男5例，女3例，年龄34~52岁，平均38.2岁。8例患者均立即中断抗病毒药物的治疗，同时给予糖皮质激素治疗，然后连续3 d甲强龙2.0 g/d冲击治疗，接着连续2周以上强尼松40 mg/d治疗。结果：本组8例干扰素治疗慢性丙肝所致间质性肺炎的患者中，其中7例患者均恢复良好，恢复时间为2~12周，平均6.5周，有效率87.5%；1例患者因病情加剧导致呼吸窘迫综合征死亡，为单独应用的干扰素患者，死亡率12.5%。结论：运用干扰素治疗慢性丙肝，会有发生间质性肺炎的可能，因此在对慢性丙肝患者治疗的时候，应该尽量避免干扰素的单独应用，尽可能的联合其他药物进行治疗，减少毒副作用的发生。%Objective:To investigate the clinical features of interferon in the treatment of interstitial pneumonia caused by chronic HCV.Method:The use of interferon in the treatment of 8 patients with interstitial pneumonia caused by chronic liver disease in our hospital from 2008 January to 2012 December,including male 5 cases,female 3 cases,age 34-52 year old,average 38.2 years old.Treatment of 8 cases of patients were immediately interrupt antiviral drugs,while giving glucocorticoid treatment,and then methylprednisolone 2.0 g/d shock treatment was given for three consecutive days,and then more than 2 consecutive weeks Jonny pine 40 mg/d treatment.Result:In this group 8 patients with interferon therapy in chronic hepatitis C caused by interstitial pneumonia,in which 7 patients were recovered,the recovery time was 2-12 weeks,an average of 6.5 weeks,the efficiency of 87.5%;because of illness exacerbate respiratory distress syndrome,1 patient died,interferon were used alone,the mortality rate was 12.5%. Conclusion:The use of interferon treatment of chronic hepatitis C,may be cause an interstitial pneumonia,therefore in the treatment of patients with chronic hepatitis C,should try to avoid a separate application of interferon,possibly in combination with other drugs,reduce the occurrence of side effects.