老年高血压患者踝肱指数与尾加压素Ⅱ相关性研究

摘要

Objective:To study the relationship of ankle-brachial index and urotensinⅡ(UⅡ)in elderly patients with hypertension,to explore the relationship of UⅡand atherosclerosis. Method:To enroll 130 cases of elderly patients with hypertension and 72 healthy elderly,the plasma UⅡconcentration and the ankle-brachial index(ankle brachial index,ABI)was measured by radioimmunoassay in all cases.According to the severity of the ABI,the hypertensive patients were divided into ABI0 /ABI1/ ABI2 three groups. At last,a comprehensive analysis of U Ⅱlevel,ankle-brachial index,in each group was deployed.Result:Compared with the healthy individuals,the ankle-brachial index in hypertensive patients was significantly reduced,in contrast the plasma U Ⅱlevels were significantly increased(P<0.01).The plasma U Ⅱlevel was negatively related to the ABI in hypertensive patients.The difference of UⅡlevel in three hypertensive groups was statistically significant(P<0.05).Conclusion:ABI in elderly hypertensive patients is negatively related with the plasma UⅡlevel and the concentration of UⅡis closely related to the Atherosclerosis.%　　目的：研究老年高血压患者踝肱指数与尾加压素Ⅱ（UⅡ）的相关性，进一步探讨UⅡ与动脉粥样硬化的关系。方法：采用放免法测定130例老年高血压患者及72例健康老年人血浆UⅡ浓度，并分别测量踝肱指数（ankle brachial index，ABI），再根据ABI严重程度将高血压患者分为ABI0、ABI1、ABI2三组。结合UⅡ水平、踝肱指数对各组进行比较分析。结果：与健康组比较，高血压患者踝肱指数明显降低，而血浆UⅡ水平明显升高（P<0.01）；高血压患者血浆UⅡ水平与ABI呈明显负相关，高血压三组UⅡ水平组间比较差异有统计学意义（P<0.05）。结论：老年高血压患者的踝肱指数与血浆UⅡ水平呈负相关，提示UⅡ浓度与动脉粥样硬化密切相关。