联合检测ADA、CEA、CRP、淀粉酶在鉴别结核性和恶性胸腔积液中的诊断价值

摘要

Objective:To investigate the combined detection of adenosine deaminase(ADA),carcinoembryonic antigen(CEA),C-reactive protein(CRP)and amylase in the diagnostic value in the differential diagnosis of tuberculous and malignant pleural effusion. Method:117 patients with pleural effusion,45 cases divided into 72 cases of tuberculous and malignant group,for each patient,specimens from the pleural effusion detected ADA, CEA,CRP and amylase. Result:tuberculous pleural effusion,ADA and CRP were higher than the malignant group,the difference was statistically significant(P<0.001);the malignant group and pleural effusion CEA and amylase were higher than the TB group,the difference was statistically significant(P<0.001). Conclusion:The combined detection of adenosine deaminase(ADA)and carcinoembryonic antigen(CEA),C-reactive protein (CRP)and amylase for the differential diagnosis of tuberculous and malignant pleural effusions have a higher reference value,and pleural effusionADA and CRP level support the diagnosis of tuberculous pleural effusion,CEA and amylase tended to the diagnosis of malignant pleural effusions.%　　目的：探讨联合检测腺苷脱氨酶(ADA)、癌胚抗原(CEA)、C 反应蛋白(CRP)和淀粉酶在鉴别结核性与恶性胸腔积液中的诊断价值.方法：选取胸腔积液患者117例，分为结核组72例和恶性组45例，每组均留取胸腔积液检测 ADA、CEA、CRP 和淀粉酶.结果：结核组胸腔积液 ADA 和 CRP 均高于恶性组，差异有统计学意义(P<0.001)；恶性组胸腔积液 CEA 和淀粉酶均高于结核组，差异有统计学意义(P<0.001).结论：联合检测腺苷脱氨酶(ADA)、癌胚抗原(CEA)、C 反应蛋白(CRP)和淀粉酶对于结核性和恶性胸腔积液的鉴别诊断有更高参考价值，胸腔积液中 ADA 和 CRP 增高时支持结核性胸腔积液诊断，而 CEA 和淀粉酶增高则倾向于诊断恶性胸腔积液.