血清降钙素原对儿童发热性疾病的诊断及临床意义

摘要

Objective:To investigate the level of procalcitonin(PCT)and peripheral blood white blood cells (WBC)and C-reactive protein(CRP)in the monitoring of febrile diseases and antibiotics. Method:The clinical data of 150 were divided into bacterial infection group(60 cases)and non-bacterial infection group(90 cases)at our hospital from May 2012 to May 2013. 40 cases with non-infection were set as control group. Result:The WBC of the three groups was(16.37±4.60)×109/L,(11.62±5.13)×109/L,(7.09±1.88)×109/L. The date of CRP of the three groups was (18.07±10.67)mg/L,(8.23±2.49)mg/L,(5.01±2.84)mg/L. The date of PCT of the three groups was(2.54±2.24)μg/L, (0.11±0.05)μg/L,(0.09±0.05)μg/L. The serum PCT and CRP levels and WBC of the bacterial infection group were higher significantly than those of the non-bacterial infection group and the control group. Conclusion:It is feasible that PCT,CRP and WBC can be as important markers for the febrile diseases and also potential application of antibiotics for the judgement of the infection.%目的：探讨血清降钙素原（PCT）、外周血白细胞（WBC）和C-反应蛋白（CRP）水平在儿童发热性疾病中的临床意义及指导抗生素的应用。方法：以河南大学淮河医院儿科2012年5月-2013年5月收治的150例发热患儿为研究对象，采用回顾性分析方法，根据出院时的诊断分为细菌感染组、非细菌感染组。检测其外周血WBC、血清PCT及CRP，并与对照组40例非发热性疾病患儿进行比较。结果：细菌感染组、非细菌感染组及对照组患儿WBC数分别为（16.37±4.60）×109/L、（11.62±5.13）×109/L、（7.09±1.88）×109/L；CRPm值分别为（18.07±10.67）mg/L、（8.23±2.49）mg/L、（5.01±2.84）mg/L；PCT值分别为（2.54±2.24）μg/L、（0.11±0.05）μg/L、（0.09±0.05）μg/L。细菌感染组外周血WBC、血清PCT及CRP均明显升高，非细菌感染组外周血WBC轻度升高，血清PCT及CRP均无明显升高。结论：联合应用外周血WBC、血清PCT及CRP对儿童发热性疾病的鉴别诊断及抗生素的应用有重要意义。