Objective:To investigate the analgesic efficacy after hysterectomy of preoperative intrathecal injection of different doses of morphine and fentanyl.Method:86 patients underwent complete hysterectomy in our hospital were selected from October 2011 to November 2012.All cases were randomly divided into the combination group 1 and the combination group 2,43 cases in each group.The combination group 1 was given 0.2 mg morphine+25μg fentanyl,the combination group 2 was given 0.5 mg morphine+15μg fentanyl.Postoperative pains of the two groups were evaluated by using visual analogue scale.Adverse events and remedial analgesia situation were compared between the two groups.Result:The exhaust time of the combination group 1 was significantly shorter than combination group 2,the difference was statistically significant (P<0.05).Each time point,the VAS scores of combination group 1 were significantly lower than combination group 2,the differences were statistically significant(P<0.05).The adverse reaction rates of combination group 1 were significantly lower than combination group 2,the differences were statistically significant(P<0.05).The remedy analgesia rate of combination group 1 was 2.3%,which was lower than combination group 2,but the difference was not statistically significant(P>0.05). Conclusion:The analgesic efficacy after hysterectomy of preoperative intrathecal injection 0.2 mg morphine+25μg fentanyl is better,low incidence of adverse reactions,good safety,and helpful to the recovery of postoperative gastrointestinal function,it is worth the clinical promotion.%目的：评价不同剂量吗啡联合芬太尼术前鞘内注射对子宫切除术后的镇痛效果。方法：选取2011年10月-2012年11月在本院择期行全子宫切除术的86例患者，按照随机数字表法将其分成联合1组和联合2组各43例，联合1组采用0.2 mg吗啡+25μg芬太尼，联合2组采用0.5 mg吗啡+15μg芬太尼，采用视觉模拟评分法对两组患者术后疼痛情况进行评价，比较两组患者不良反应发生和补救镇痛情况。结果：联合1组的排气时间明显短于联合2组，差异有统计学意义（P<0.05）；各时间点，联合1组的VAS评分均明显低于联合2组，差异均有统计学意义（P<0.05）；联合1组不良反应发生率均低于联合2组，差异均具有统计学意义（P<0.05），联合1组补救镇痛率为2.3%，低于联合2组的7.0%，但差异无统计学意义（P>0.05）。结论：0.2 mg吗啡+25μg芬太尼用于子宫切除患者术前鞘内镇痛效果较佳，不良反应发生率低，安全性较好，且有助于术后胃肠功能恢复，值得临床推广。
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