43例IgA肾病患者糖皮质激素治疗临床分析

摘要

Objective:To evaluate the therapeutic effect of glucocorticoid in the treatment of IgA nephropathy.Method:A total of 43 cases of IgA nephropathy in our hospital from March 2005 to March 2015 were selected as the research object,they were treated with glucocorticoid therapy,24 h urine protein quantitation,creatinine clearance rate before and after treatment,clinical efficacy and adverse reactions were observed.Result:After treatment,24 h urinary protein quantitation was significantly lower than before treatment,the difference was statistically significant(P<0.05),but there was no significant difference in the creatinine clearance rate before and after treatment(P>0.05).After treatment,23 cases were markedly excellent, 14 cases were effective,6 cases were ineffective,the effective rate of treatment was 86.0%.There were 5 cases of upper respiratory tract infection,2 cases of gastric ulcer,and the incidence of adverse reactions was 16.3%. Conclusion:Glucocorticoid can reduce the urinary protein of IgA nephropathy patients,it has a certain clinical application value.%目的：评价糖皮质激素治疗IgA肾病的治疗效果。方法：选取2005年3月-2015年3月本院收治的IgA肾病患者43例作为研究对象，给予糖皮质激素治疗，观察患者治疗前后24 h尿蛋白定量和肌酐清除率情况、临床疗效及不良反应。结果：治疗后，24 h尿蛋白定量较治疗前明显下降，比较差异有统计学意义（P<0.05），但肌酐清除率治疗前后比较差异无统计学意义（P>0.05）；治疗后显效23例、有效14例、无效6例，治疗有效率86.0%；上呼吸道感染5例，胃溃疡2例，不良反应发生率16.3%。结论：糖皮质激素能够减少IgA肾病患者尿蛋白含量，具有一定的临床应用价值。