高渗葡萄糖溶液在持续性异位妊娠治疗中的临床分析

摘要

To investigate the application value of hyperosmolar glucose in the therapy for persistent ectopic pregnancy (PEP). Methods:75 patients with PEP were divided into two groups from Jan 2011 to Dec 2013. 45 cases were in the observation group and hyperosmolar glucose was injected into the fallopian tube combined with B ultrasound monitoring in operation. 30 cases were in the control group and methotrexate (MTX) was injected intramuscular injection. The successful rate, adverse reaction and recovery time of β-hCG were compared between the two groups. Results:Compared with the control group,the successful rate in the observation group was significantly higher (95.6% vs 70.0%,P < 0.05),the adverse reaction rate was significantly lower (4.4 % vs 26.7%,P < 0.05) and the recovery time of β-hCG was significantly shorter (14.2 ±5.9d vs 19.4 ±4.6 d,P < 0.01). Conclusion:Compared with the MTX,hyperosmolar glucose is an effective and safe method for patient with PEP.%目的：探讨高渗葡萄糖溶液在持续性异位妊娠（PEP）治疗中的应用价值。方法：将2011年1月至2013年12月诊治的PEP患者75例分成观察组和对照组，观察组45例在B 超监视妇科手术仪监视下经宫腔输卵管注入50％葡萄糖溶液，对照组30例予甲氨蝶呤（MTX）肌肉注射，比较对两组治疗成功率、不良反应率及β-hCG 转阴时间。结果：观察组的治疗成功率明显高于对照组（95．6％ vs 70．0％，P ＜0．05），不良反应发生率明显低于对照组（4．4％ vs 26．7％，P ＜0．05），β-hCG 转阴时间显著少于对照组（14．2±5．9 d vs 19．4±4．6d，P ＜0．01）。结论：与甲氨蝶呤相比较，高渗葡萄糖溶液对PEP治疗更有效安全。