华法林药物基因组学的发展及其临床应用前景

摘要

华法林是临床广泛使用的口服抗凝药物。由于自身狭窄的有效抗凝治疗范围以及个体间每日用药剂量的显著差异，困扰着许多患者和临床医生。近年来，许多研究均报道基因多态性是引起华法林个体间用药剂量差异的主要因素之一。部分学者建立基于药物基因组学的剂量方程，并在进行验证，评估其临床价值。本文综述了华法林相关药物基因组学的国内外最新进展，为进一步针对华法林的临床研究提供参考依据。%Warfarin,a commonly prescribed anticoagulant,has warried lots of patients and doctors because of its narrow therapeutic range and large interindividual variability in daily dose.During recent years,many studies focus on genetic polymorphisms,regarding it as one of the main effects which lead to dose difference between individuals.Some of them established and verified pharmacogenetic-based warfarin-dosing algorithms and evaluated the clinical significance.Our review exhibits the latest development of warfarin-related pharmacogenomics home and abroad,in order to provide references for further clinical studies.