非酒精性脂肪肝患者血清瘦素和胰岛素抵抗水平的研究

摘要

Objective To study the levels of Leptin,insulin and insulin resistance in patients with nonalcoholic fatty disease.Methods 40 patients with nonalcoholic fatty liver disease were selected for this study as nonalcoholic fatty liver disease group and 40 healthy subjects were set up as control group.The serum levels of fasting blood glucose,fasting insulin,blood lipids,Leptin,body weight and height were measured,Their body mass index(BMI)and HOMA-IR were calculated.Results (1)The serum of Leptin and Insulin in the patients with nonalcoholic fatty liver disease group were significantly higher than those of control group (P<0.05);(2)Significant correlations were found among the nonalcoholic fatty liver disease with Leptin,Insulin and HOMA-IR.Conclusion The high serum levels of Leptin, Insulin and Insulin resistance play important roles in the initiation of nonalcoholic fatty liver disease.%目的 了解非酒精性脂肪肝患者血清瘦素、胰岛素和胰岛素抵抗的水平.方法 选择非酒精性脂肪肝患者40例和健康对照组40例,测定所有研究对象的空腹血糖(FPG)、空腹胰岛素(Inso)、血脂、血清瘦素(Leptin)、身高、体质量,计算其体质量指数和胰岛素抵抗(HOMA-IR).结果 (1)非酒精性脂肪肝组Leptin和HOMA-IR均显著高于健康对照组,差异有统计学意义(P<0.05);(2)通过多元回归相关分析发现,非酒精性脂肪肝与Leptin、Inso及HOMA-IR均呈独立正相关.结论 高Leptin、高Inso和HOMA-IR在非酒精性脂肪肝发病中起重要作用.