Objective: to study the correlation of serum leptin and insulin resistance with non-alcoholic fatty liver, and to explore the effect of Tuina on abdomen on leptin and insulin resistance in patients with non-alcoholic fatty liver. Methods: 99 cases served as the objects of study, which were divided by random digits table into treat ment group and control group. The control group were administrated with silybin meglumine 200mg three times a day for 30 days as a course while the treatment group were given tuina once a day for 30 days, both under the guid ance of diet and exercise. Detect the leptin level and endocrine metabolism indexes before and after treatments. Re sults : the leptin level in cases with insulin resistance and alcoholic fatty liver is higher than that in cases with non insulin resistance and non-alcoholic fatty liver ( P <0. 05 ). Compared with control group, the serum leptin level of treatment group was increased significantly ( P <0. 05 ). Conclusion: Tuina on abdomen is effective in treating non-alcoholic fatty liver which is relevant to improving the hyperleptinemia and insulin resistance.%目的:研究血清瘦素水平及胰岛素抵抗与非酒精性脂肪肝的相关性,探讨腹部推拿对非酒精性脂肪肝患者血清瘦素水平及胰岛素抵抗的影响.方法:选择非酒精性脂肪肝患者99 例作为研究对象,按随机数字表法随机分为治疗组与对照组.对照组患者在饮食、运动指导的基础上,加用水飞蓟宾葡甲胺片 200 mg口服,每日 3 次,疗程共 30 d.治疗组在饮食、运动指导的基础上,加用腹部推拿1次/d,疗程共 30 d.治疗前后测定血清瘦素水平及内分泌代谢指标.结果:胰岛素抵抗非酒精性脂肪肝患者瘦素水平明显高于非胰岛素抵抗非酒精性脂肪肝患者患者( P＜ 0.05).治疗组与对照组相比,血清瘦素水平明显升高(P＜ 0.05).结论:腹部推拿治疗非酒精性脂肪肝与改善高瘦素血症及胰岛素抵抗有关.
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