心肌标志物及心肌酶检测在活动性巨细胞病毒感染婴幼儿中的临床应用

摘要

Objective To study the change characteristics of cardiac markers and cardiac enzymes in infants with active cytomegalovirus (CMV) infection .Methods 150 children patients with CMV infection in the pediatric de-partment of our hospital from January 2011 to December 2013 were selected as the observation group and 80 healthy infants with physical examination from August to December 2013 were selected as the control group .Serum creatine phosphate kinase(CK) ,isoenzyme(CK-MB)and troponin I(cTnI) were detected in the observation group before and after treatment and the control group .Results The levels of cTnI ,CK ,CK-MB and CK-MB/CK before therapy in the observation group were significantly higher than those in the control group ,the difference was statistically signifi-cant(P<0 .01);the levels of cTnI ,CK ,CK-MB and CK-MB/CK after treatment in the observation group were signif-icantly lower than those before treatment ,the difference was statistically significant (P<0 .01) .Conclusion The lev-els of cardiac markers and cardiac enzymes in infants with active CMV infection are elevated .This change is reversible after acyclovir treatment .The changes of cardiac markers and myocardial enzyme spectrum can prompt the active CM V infection .%目的：研究活动性巨细胞病毒感染婴幼儿的心肌标志物与心肌酶的变化特点。方法选取该院儿科于2011年1月至2013年12月收治的150例巨细胞病毒感染患儿作为观察组，选取于2013年8月至2013年12月至该院体检的80例健康婴幼儿作为对照组，检测两组研究对象治疗前后的血清磷酸肌酸激酶（C K ）及其同工酶（CK-MB）、肌钙蛋白I（cTnI）。结果观察组治疗前的cTnI、CK、CK-MB、CK-MB/CK均明显高于对照组，差异有统计学意义（P＜0．01）；观察组治疗后的 cTnI、CK、CK-MB、CK-MB/CK 均明显低于治疗前，差异有统计学意义（P＜0．01）。结论活动性巨细胞病毒感染婴幼儿的心肌标志物和心肌酶会升高，经过更昔洛韦的治疗后这种改变是可逆的，心肌标志物与心肌酶谱的变化可以提示活动性巨细胞的感染。