Objective To understand the main pathogens and intestinal viruses causing infantile infectious di-arrhea in the eastern area of Shenzhen city so as to provide reference for the prevention and control of diseases and clinical medication .Methods 1 095 stool samples of infantile diarrhea in the eastern area of Shenzhen city were col -lected and simultaneously performed the routine pathogen culture and the nucleic acid detection of intestinal viruses including rotavirus ,Norovirus ,astrovirus enteric adenovirus .Results Among 1 095 collected stool samples of infan-tile diarrhea ,215 strains of pathogenic bacteria were detected out with the positive rate of 19 .63% ,in which diarrhea-causing Escherichia coli was predominant and summed to 135 strains .Among Escherichia coli ,enteropathogenic Esch-erichia coli (EPEC) was maximal and accounted for 57 .04% ,enterotoxigenic E .coli (ETEC) accounted for 37 .04%and enteroinvasive E .coli (EIEC) accounted for 5 .19% .1 case of Enterohemorrhagic E .coli(EHEC) O157 ∶ H7 was detected ;followed by Salmonella(4 .11% ) and Staphylococcus aureus (2 .28% ) .The total positive rate of enterovirus was 23 .83% ,the detection rates of rotavirus ,norovirus ,astrovirus and enteric adenovirus were 9 .04% ,13 .97% , 0 .73% and 0 .64% respectively .Conclusion June -December each year is the peak period of bacterial infection diar-rhea .The pathogenic bacteria in the eastern area of Shenzhen are mainly diarrhea-causing E .coli bacteria ,Salmonella and Staphylococcus aureus .Young children under 2 years old should be vigilant to the possibility of Staphylococcus aureus infection .The incidence rate of viral diarrhea shows an increasing trend year by year ,in which norovirus and rotavirus are the main pathogens .Autumn and winter are the peak period of viral infection .Aiming at the characteris-tics of infectious diarrhea in this area ,the monitoring work should be timely done well ,the management of the preven-tion and treatment works should be paid high attention to ,and the input of the manpower and material resources should be increased .%目的：了解导致深圳市东部地区婴幼儿感染性腹泻的主要致病菌及肠道病毒，获得该地区婴幼儿感染性腹泻病原谱，为预防控制疾病及临床用药提供参考依据。方法收集深圳市东部地区2010年1月至2012年12月腹泻婴幼儿的粪便标本1095例，进行致病菌常规培养，同时进行肠道病毒（包括轮状病毒、诺如病毒、星状病毒和肠道腺病毒）的核酸检测。结果1095例腹泻粪便标本中，检出致病菌215株，阳性率为19．63％，以致泻性大肠埃希菌为主，共135株，其中致病性大肠埃希菌最多，为57．04％，产毒性大肠埃希菌为37．04％，侵袭性大肠埃希菌为5．19％，检出1例肠出血性大肠埃希菌 O157∶ H7；其次是沙门菌（4．11％）；再次是金黄色葡萄球菌（2．28％）。肠道病毒的总阳性率为23．83％，其中轮状病毒、诺如病毒、星状病毒和肠道腺病毒的检出率分别为9．04％、13．97％、0．73％和0．64％。结论每年6～12月为细菌感染腹泻的高峰期，深圳市东部地区婴幼儿腹泻病原菌以致泻性大肠埃希菌、沙门菌及金黄色葡萄球菌为主要病原菌，＜2岁的低龄儿童应警惕感染金黄色葡萄球菌的可能性。病毒性腹泻发病率呈逐年上升趋势，其中诺如病毒和轮状病毒是主要的病原体。每年秋、冬季为病毒感染发病高峰期。针对深圳市东部地区婴幼儿感染性腹泻的特点，应及时做好监测工作，应高度重视对防治工作的管理并加大人力、物力投入。
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