亚洲地区KCNJ11E23K基因多态性与2型糖尿病关系的Meta分析

摘要

Objective To investigate the correlation between KCNJ11 E23K gene polymorphism with type 2 diabetes mellitus(T2DM ) in the Asian population .Methods The case‐control study on the relationship between KC‐NJ11 E23K gene polymorphism and T2DM in Asian population were entirely retrieved from PubMed ,CNKI ,VIP da‐tabases .The statistical analysis was performed by the Stata12 .0 software .Results 10 eligible articles were included in this study ,the data were pooled with the random effect model(D‐L method) ,the results showed that the K allele frequency of the patients group was significantly higher than that of the control group(OR = 1 .16 ,95% CI = 1 .08 -1 .25 ,P= 0 .00) .Conclusion The KCNJ11 E23K gene polymorphism is correlated with the increase of T2DM onset risk in Asian population .%目的：探讨在亚洲地区内向整流钾通道亚家族成员11（KCNJ11）E23K 基因多态性与2型糖尿病（T2DM ）的相关性。方法以 PubMed 、中国知网、维普等为搜索数据库，全面检索关于亚洲人群 KCNJ11 E23K 基因多态性与 T2DM 相关性的随机病例对照研究，并用 Stata12．0软件进行统计分析。结果共10篇符合条件的文献被纳入，经随机效应模型（D‐L 法）合并数据，结果显示，病例组 K 等位基因频率较对照组高，OR ＝1．16，95％ CI ＝1．08～1．25，P＝0．00。结论亚洲地区 KCNJ11 E23K 基因多态性与 T2DM 发病风险增高相关。