Association of PPARG Gene Polymorphisms Pro12Ala with Type 2 Diabetes Mellitus: A Meta-analysis

摘要

Background: Previous studies suggested that the single nucleotide polymorphisms ofPro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, thegenetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each studywere shown to be inconsistent. Moreover, the systematic review has not been updated since 2000.Objective: To further validate the risk of Pro12Ala for T2DM disease based on the genetic data.Methods: The genetic studies on the Pro12Ala in the T2DM were searched in the PubMed and PMCdatabase from January 2000 to October 2017. The meta-analysis was conducted with the CMA software.Results: The meta-analysis collected 14 studies including 20702 cases and 36227 controls. The combinedanalysis of all studies found that Pro12Ala was shown to be significantly associated with T2DMand the Ala allele played the increasing risks for the disease. Nevertheless, publication bias was detectedin the combined analysis. The subgroup analysis indicated that Pro12Ala was found to besignificant in the Caucasian and Chinese population. There was no heterogeneity and publication bias inthese two groups.Conclusion: The meta-analysis confirmed the evidence that the Pro12Ala was the susceptible variantfor the decreasing risks for the T2DM.