中西医结合治疗早期2型糖尿病肾病疗效及对血清超氧化物歧化酶、丙二醛水平的影响

摘要

Objective To investigate the clinical effects of TCM combined with western medicine in the treatment of patients with diabetic nephropathy in early stage and influence on SOD and MDA .Methods A total of 64 patients with diabetic nephropathy in early stage were chosen in the period from May 2014 to Janu-ary 2017 in our hospital and randomly divided into both group including control group (32 patients) with western medicine used alone and observation group (32 patients) with Yiqiziyinbuxue decoction on the basis of control group ;and the clinical effects ,the TCM scores ,the levels of FPG ,2 hPG ,Scr ,BUN ,UAL ,SOD and MDA before and after treatment of both groups were compared .Results The clinical effects of observation group were significantly better than control group (P＜0 .05).The TCM scores after treatment of observation group were significantly lower than control group and before treatment (P＜0 .05).There was no significant difference in the levels of FPG and 2 hPG before and after treatment between 2 groups (P＞0 .05).The levels of Scr ,BUN and UAL after treatment of observation group were significantly lower than control group and before treatment (P＜0 .05).The levels of SOD and MDA after treatment of observation group were signifi-cantly better than control group and before treatment (P＜0 .05).Conclusion TCM combined with western medicine in the treatment of patients with diabetic nephropathy in early stage can efficiently relieve the clinical symptoms and signs ,improve the renal function ,regulate the levels of oxidative stress index ,and have no ad-verse effects on blood glucose .%目的 探讨中西医结合治疗早期 2 型糖尿病肾病疗效及对血清超氧化物歧化酶(SOD)及丙二醛(MDA)水平的影响.方法 选取2014年5月至2017年1月收治的早期糖尿病肾病患者64例为研究对象,分为对照组(32例)和观察组(32例) ,对照组给予西药单用治疗,观察组在此基础上加用益气滋阴补血方辅助治疗;比较两组患者的临床疗效,治疗前后中医证候积分、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、血肌酐(Scr)、尿素氮(BUN)、尿清蛋白(UAL)、血清SOD及MDA 水平等.结果 观察组临床疗效明显优于对照组(P＜0 .05) ;观察组治疗后中医证候积分均显著低于治疗前及对照组治疗后(P＜0 .05) ;两组患者治疗后FPG 和2 hPG水平比较差异无统计学意义(P＞0 .05) ;观察组患者治疗后Scr、BUN及UAL水平均显著低于治疗前及对照组治疗后(P＜0 .05) ;同时观察组患者治疗后SOD和MDA水平均明显优于治疗前及对照组治疗后(P＜0 .05) .结论 中西医结合治疗早期2型糖尿病肾病可有效缓解相关症状体征,改善肾脏功能,调节氧化应激指标水平,且未对血糖水平产生不利影响.