左旋肉碱对肥胖患者血脂水平影响的 meta分析

摘要

Aim:To evaluate the relationship between L-carnitine and lipid levels in obese patients .Methods: Ac-cording to the requirements of system evaluation , randomized controlled trials of L-carnitine for weight loss were collected . The quality of the included studies was evaluated and meta-analysis was performed .Results: Reduction in the TG (WMD=0.883,95%CI=-0.230-1.980,Z=1.560,P=0.120), TC(WMD=-0.060,95%CI=-0.150-0.020, Z=1.520,P=0.130), and HDL(WMD=0.040,95%CI=-0.270-0.360,Z=0.270,P=0.790) between the inter-vention and control groups had no statistical difference; LDL reduction(WMD=1.080,95%CI=-0.560-2.730,Z=1.290,P=0.020) between the 2 groups had statistical difference .Conclusion:L-carnitine could improve the LDL level of obese patients thus regulating the fat metabolism in obese patients .%目的：采用meta分析明确左旋肉碱与肥胖患者血脂水平的关系。方法：按照系统评价的要求，检索左旋肉碱用于减肥的随机对照试验，对纳入的研究进行质量评价和meta分析。结果：试验组和对照组在 TG减少（WMD＝0．883，95％CI＝－0．230～1．980，Z＝1．560，P＝0．120）、 TC减少（WMD＝－0．060，95％CI＝－0．150～0．020，Z＝1．520，P＝0．130）、HDL减少（WMD＝0．040，95％CI＝－0．270～0．360，Z＝0．270，P＝0．790）方面差异均无统计学意义，在LDL减少（WMD＝1．080，95％CI＝－0．560～2．730，Z＝1．290，P＝0．020）方面差异有统计学意义。结论：左旋肉碱通过改善肥胖患者的LDL水平，调控肥胖患者脂肪代谢。