目的：探讨肝功能衰竭预后的影响因素。方法回顾性分析2008年1月—2013年6月新疆医科大学第一附属医院感染性疾病中心收治的436例肝功能衰竭患者，分析患者一般情况、肝功能衰竭病因。并根据患者3个月的生存情况将所有患者分为生存组和死亡组，比较两组并发症、各实验室指标水平，进行单因素 Logistic回归分析，找出的对肝功能衰竭预后具有影响的因素，进行多因素的 Logistic 回归分析找出影响肝功能衰竭预后的独立危险因素。结果436例肝功能衰竭患者单因素回归分析显示年龄、肝肾综合征、消化道出血、肝性脑病、自发性腹膜炎、腹水、总胆红素、直接胆红素、肌酐、尿素氮、凝血酶原时间、国际标准化比率、白细胞、中性粒细胞百分比、中性粒细胞计数与肝功能衰竭患者预后相关；多因素 Logistic 回归分析显示，年龄、肝性脑病、肝肾综合征、凝血酶原时间4个因素是影响肝功能衰竭预后的独立危险因素。结论年龄、肝性脑病、肝肾综合征、碱性磷酸酶、凝血酶原时间对预测肝功能衰竭预后具有较高价值。%Objective To analysis the prognosis factors of liver failure.Methods Retrospective analysis of 436 cases of patients with liver failure from Department of Infection,the First Affiliated Hospital of Xin-jiang Medical University between January,2008 and June,2013.Results This research involves the com-plications in gastrointestinal bleeding,spontaneous peritonitis,hepatic encephalopathy,hepatorenal syn-drome were statistically significant difference between survival group and death group.Single factor regres-sion analysis showed,patients′ age,gastrointestinal bleeding,hepatic encephalopathy,hepatorenal syn-drome,spontaneous peritonitis,ascites,total bilirubin,direct bilirubin,urea nitrogen,creatinine,pro-thrombin time,ratio of international standardization,white blood cells,neutrophil count are correlated with the prognosis; Multivariate Logistic regression analysis showed patient′ s age, hepatic encephalopathy,hepatorenal syndrome,prothrombin time were the independent risk factors influencing the prognosis of liver failure.Conclusion It is suggested that age,hepatic encephalopathy,hepatorenal syndrome,alkaline phosphatase,and prothrombin time were the independent risk factors influencing the prognosis of liver failure.
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