EGCG对肾缺血再灌注损伤的保护作用及其作用机制的研究

摘要

The study aims to investigate potential protection and mechanism of epigallocatechin gallate(EGCG) on kidney ischemia reperfusion injury. The results showed that EGCG treatment improved renal dysfuction, pathlogical change of kidney tissues, and reduced the expression of Wnt3a, β-catenin, MDA, IL-6, IFN-γ and TNF-α, but increased the levels of CAT, GPX and SOD, suggesting that EGCG can protect the kidney from ischemia-reperfusion injury in rats which is associated with suppressing the activation of Wnt/β-catenin/p53 signaling pathway and inhibiting inflammation and oxidative stress.%探讨了表没食子儿茶素没食子酸酯(EGCG)对大鼠肾缺血再灌注损伤的保护作用及其机制.结果表明,与肾缺血再灌注损伤模型组相比,EGCG组肾功能改善,肾组织病理改变,Wnt3a、β-catenin、p53、p21、MDA、IL-6、IFN-γ和TNF-α表达明显减少,而CAT,GPX和SOD表达明显增加.说明EGCG预处理减轻肾缺血再灌注损伤与抑制Wnt3a/β-catenin/p53信号通路介导的炎症反应和氧化应激相关.