前列地尔注射液治疗老年AECOPD合并肺动脉高压的疗效观察

摘要

Objectives To explore Prostaglandin E1 treatment of Elderly patients with acute exacerbation chronic obstructive pulmonary disease and pulmonary hypertension,view of the efficacy and safety,Observe the SPAP,DPAP,MPAP and Right heart sys-tolic function cardiac function before and after the treatment change.Methods Elderly patients with acute exacerbation chronic ob-structive pulmonary disease patients with of 128 patients were randomly divided into Prostaglandin E1 group of 64 patients and the control group of 64 patients,Prostaglandin E1 group were given Prostaglandin E1 10ug in subcutaneous injection,14 days for a course of treatment,Both groups were using conventional anti infective,phlegm,cough,and other symptomatic therapy.Results Prostaglan-din E1 for the group were 71.4%,54.2%for the control group,Prostaglandin E1 group,the total efficiency of 92.1%,82.8% for the control group,Observation group SPAP,DPAP,MPAP was significantly lower than the control group,the observation group RVEF increased significantly.The difference between the two groups was significant ( P<0.05 ) .Conclusions Prostaglandin E1 treat-ment of elderly patients with acute exacerbation chronic obstructive pulmonary disease is efficacious.%目的：探讨前列地尔治疗老年慢性阻塞性肺病急性加重（ AECOPD）合并肺动脉高压（ PH）的疗效。方法根据治疗方案将2013年3月～2014年12月我院收治的128例AECOPD合并PH患者分为观察组与对照组，观察组患者64例，对照组患者64例。两组患者均常规给予抗感染、解痉、祛痰等基础治疗，观察组患者在常规治疗基础上联合使用前列地尔注射液（PGE1），静脉注射，10μg／次，1次／天。对比分析经治疗后两组患者的临床疗效、不良反应，同时超声检查评价肺动脉收缩压（ SPAP）、肺动脉舒张压（ DPAP）、平均肺动脉压（ MPAP）、右室射血分数（ RVEF）。结果治疗前，两组患者肺动脉压、右室射血分数相比差异无统计学意义（P＞0．05）。治疗后，观察组SPAP、DPAP、MPAP显著低于对照组，RVEF显著高于对照组，差异有统计学意义（P＜0．05）。观察组治疗效果显著优于对照组，差异有统计学意义（P＜0．05）。观察组不良反应发生率与对照组相比，差异没有统计学意义（ P＞0．05）。结论前列地尔注射液治疗AECOPD合并PH的疗效确切，且安全性好，是治疗AECOPD合并PH的理想药物。