四补益青颗粒剂的制备及抗湿性研究

摘要

以吸湿性、成型率、休止角等为考察指标,对四补益青颗粒剂的处方、成型工艺及抗湿性进行了研究.确定了四补益青颗粒剂的处方为混合辅料(乳糖:MCC=1.5:1):浸膏=4:1;最佳成型工艺为混合辅料(乳糖:MCC=1.5:1):浸膏=4:1混合均匀,过14目筛,60℃干燥,整粒,即得.四补益青颗粒剂的临界相对湿度为67.68％ 、成型率为94.56％,休止角小于30°,结果表明,该法制出的颗粒成型率高、溶解性好、流动性好,具有较好的抗湿性.%Optimum forming process ,moisture resistance of Four Tonic Green granules were selected with moisture rate ,forming ratio and angle of repose as indexes .Optimum composi-tion of prescription was :mixed materials (lactose: MCC = 1 .5:1): extract = 4:1 ;Preparation process was :mixed materials (lactose:MCC = 1 .5:1 ): extract = 4 : 1 mixed ,over 14 mesh sieve ,dried 1 h under 60 ℃ ,granulated .T he critical relative humidity was 67 .68％ ,the forming ratio was 94 .56％ ,the angle of repose was less than 30° .Conclu-sion:under this process ,prepared granule had high forming ratio ,high dissolubility good flowability and low hygroscopicity .