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Process for the preparation of wet granulacao tablets containing paroxetine hydrochloride pharmaceutical anidrato
Process for the preparation of wet granulacao tablets containing paroxetine hydrochloride pharmaceutical anidrato
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机译:制备含有盐酸帕罗西汀苯甲酰胺的湿性颗粒剂的方法
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摘要
Pharmaceutical tablets containing crystalline paroxetine hydrochloride anhydrate are prepared using a process comprising an initial wet granulation process in which an aqueous granulation liquid is added to a mixture of said anhydrate an excipients under high-shear conditions and the thus obtained wet granules are dried using a fluidized bed technique to obtain a water activity within a specified range, after which the dried granules after addition of further adjuvants are compressed into stable tablets each having an identical composition.
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