目的:探讨中性粒细胞CD64的表达对重症手足口病患儿的诊断价值.方法:选择在我院住院的手足口病初诊患儿共134例,其中重症组为 52例,普通组为 82例,应用流式细胞术测定中性粒细胞CD64,同时测外周血C反应蛋白(CRP)、白细胞及分类.结果:重症组CD64水平为(14.11±9.08)平均荧光强度(MFI),明显高于一般感染组(10.75±3.88)MFI( P<0.05),以CD64≥10.5MFI为阳性标准,CD64在重症组的阳性率为51.9%,普通组患儿为10.9%,两者阳性率有统计学差异(P<0.01).结论:中性粒细胞CD64的表达适用于重症手足口病感染病情的监测,而且还可作为抗生素应用的依据.%Objective To explore the clinical value of expression of peripheral blood neutrophil CD64 in children with severe hand-foot-mouse desease(HFMD). Methods 134 patients were divided into two groups, severe group has 52 patients and ordinary group has 82 patients,using flow-cytometry determination of CD64,C-reactive protein(GRP) ,white blood cell(WBC) count and pre-centage of neutrophil estimation of each patient. Results The expression of CD64 in the patients with severe group was( 14.11 9.08) MFI. Which was significantly higher than that in the ordinary group (10.75 3.88) MFI. These markers were considered positive if CD64≥10.5MFI. The positive rate of the severe group is 51.9% , which of the ordinary is 10.9% , there is statistical significance be-tween two groups. Conclusion Expression of peripheral blood neutrophil CD64 can be applied monitoring the pathosis of severe hand-foot-mouth disease, it can also be used as the basis for application of antibiotics.
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